Some believe that the two are perfectly compatible, while others think they should never be combined. In this blog post, we’ll explore the evidence for and against antidepressants and LSD compatibility. We will also discuss the potential risks of combining these two drugs.


  • Taking antidepressants and LSD is a bad idea
  • Most antidepressants trigger serotonin receptors in the brain, just like LSD. Combining the two is dangerous ⚠️
  • LSD combined with psychotherapy (but not other medications) can decrease symptoms of depression, but more research is needed on the topic 🔍

Antidepressants and LSD: Effects on Serotonin Receptors

Most antidepressants and LSD should not be taken together because both drugs cause changes in the serotonin system. Serotonin is a neurotransmitter that helps regulate mood, emotion, sleep, memory, and appetite.

Taking antidepressants and LSD at the same time can result in dangerously high levels of serotonin in the brain, which leads to a condition known as serotonin syndrome. Symptoms include:

  • agitation;
  • confusion;
  • rapid heart rate;
  • high blood pressure;
  • sweating; and
  • tremors. 

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Not all antidepressants are serotonergic, but the most popular ones – like Prozac (fluoxetine) – are. They belong to a group known as SSRIs (selective serotonin reuptake inhibitors).

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Do Classic Psychedelics (Like Psilocybin) Work as Antidepressants?

Yes, classic psychedelics such as LSD and psilocybin can have a therapeutic use (for example, to treat depression). Studies and clinical trials have confirmed it. Their effects are often long-lasting, meaning the benefits could last for several months after a single dose.

However, these are all small studies, and more research is needed to fully understand the potential of psychedelic drugs as an alternative to antidepressant medications.

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Did You Know… 🔍

Ketamine is a drug that produces hallucinations similarly to LSD, but its working mechanism is very different (dissociative rather than psychedelic). Its side effects are more severe, but interestingly, it’s an approved medication for treatment-resistant depression.

Can I Take Psychedelics With Antidepressant Medications?

It is important to note that antidepressants and LSD are not recommended for use together. There are no studies that show any beneficial effects when taking both drugs at the same time. Given the risk of serotonin syndrome, it is best to avoid mixing these two substances.

Can I Take Psychedelics With Antidepressant Medications?

Psychedelic experience can mask, enhance or complicate the antidepressant effects, depending on the individual. It is also important to understand that psychedelics and hallucinogens can cause profound psychological changes, so it is important to be aware of this when taking any form of medication.

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FAQs About Antidepressants and LSD

Is It Safe to Take Antidepressants and LSD Together?

Combining the powerful effects of antidepressants and LSD can have bad consequences. While a mix of these drugs may sound appealing, it’s highly discouraged due to dangerous interactions that could cause an overdose or impair judgment, as well as increasing risk for mental health issues.

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What Are the Risks of Combining Antidepressants and LSD?

Combining antidepressants and LSD may lead to serotonin syndrome, characterized by rapid heart rate, agitation and confusion. In addition, the subjective effects of psychedelics can be diminished by SSRI antidepressants, which act on the same brain pathways that interact with psychedelics.

Are There Any Benefits to Combining Antidepressants and LSD?

It’s not advisable to mix antidepressants and LSD – the two don’t pair well, as there are no known benefits from doing so. In fact, it can be extremely hazardous, so caution is strongly advised when dealing with both of these substances alone or together.

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