Psychedelics like psilocybin have been long discussed for their therapeutic potential. Some even claim, small doses of the psychoactive substance work just as well as antidepressants.

In this article, we will discuss Prozac and shrooms: what they are, the potential effects of them combined, and the possibility of replacing one with another. 


  • Prozac and shrooms both affect the serotonin system ✨
  • Magic mushrooms are a psychedelic substance, but when microdosed the effects are less potent.
  • There is too little research to deem shrooms a safe treatment for mental disorders.
  • Prozac and shrooms should NOT be used together, nor should shrooms replace the Prozac if it was prescribed. 

Prozac and Shrooms Combined

Prozac and Shrooms

It is not recommended to combine Prozac and shrooms, as the combination of the two drugs carries a high risk of adverse effects. It is possible that combining the two will end up with increased anxiety, confusion, and hallucinations.

One may also suffer from the serotonin syndrome. It is a dangerous and life-threatening condition.

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Microdosing Shrooms While on Prozac

Anecdotal evidence suggests that microdosing magic mushrooms boosts the effects of the SSRIs. A low dose of psilocybin doesn’t result in a psychedelic experience, but it does result in an enhanced mood and a sense of calm.

See also:  Molly and Shrooms: How They Affect the Brain. Mixing MDMA & Psychedelic Mushrooms

Sadly, at the moment, we lack the research and clinical trials to fully support this claim. 

“It is under-powered and does not prove that psilocybin is a better treatment than standard treatment with escitalopram for major depression. However, it offers tantalizing clues that it may be.”

~ Guy Goodwin, professor of psychiatry at the University of Oxford.

Prozac and Its Antidepressant Properties

Prozac and Its Antidepressant Properties

Prozac (fluoxetine) is an antidepressant drug that belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs).

It is used to treat severe depression, panic disorder, bulimia nervosa, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), and post-traumatic stress disorder (PTSD).

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The way Prozac works is that it increases levels of serotonin, a neurotransmitter in the brain that is involved in regulating mood. It does this by blocking the reuptake of serotonin, which means that more serotonin remains in the synapse between two neurons, making it available for longer.

This increased availability of serotonin in the brain helps to balance mood and reduce symptoms of mental health disorders. 

Serotonin Reinforcements: Psilocybin vs SSRI

  • Serotonin is a neurotransmitter that is involved in a variety of functions in the body, including mood regulation, appetite, sleep, and memory. Serotonin also plays an important role in regulating behavior.
  • Psilocybin is a naturally occurring psychedelic compound found in certain types of mushrooms. It is thought to act on serotonin receptors and has been studied for its potential to help with depression, anxiety, and addiction.
  • Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs commonly used to treat depression and anxiety by increasing serotonin levels in the brain. SSRIs work by blocking the reuptake of serotonin, allowing more serotonin to remain active in the brain.

Psychedelics in Mental Health Series: Psilocybin

Both psilocybin and SSRIs can increase serotonin in the brain, but they do so in different ways. Psilocybin binds to serotonin receptors and has been found to increase brain serotonin levels directly, while SSRIs work by blocking the reuptake of serotonin, allowing more serotonin to remain active in the brain.

See also:  Kratom and Shrooms: Two Psychoactive Substances of Natural Origin

Psilocybin is associated with a range of psychological effects, including altered perception, increased creativity, improved mood, and decreased anxiety. It is thought to help with depression, anxiety, and addiction.

However, the effects of psilocybin are not well understood and research is ongoing. It is important to note that psilocybin is a Schedule I drug in the United States and is illegal to possess or use. 

Shrooms Instead of Prozac 

Shrooms Instead of Prozac

In general, taking psychedelic substances like LSD, MDMA or shrooms without a professional supervision is risky. And it is even riskier to attempt self-medication with shrooms instead of the prescribed medicine.

Take into consideration that you’ve been prescribed a specific substance by a qualified doctor. They know how the antidepressants work, and you should trust them when they say they will help you. 

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We do acknowledge that the serotonergic antagonist psilocybin has been researched as a potential treatment of depression, anxiety and other mental conditions.

If it ever gets approved to be used as an alternative to antidepressants, it would revolutionize the way the society looks at the psychedelics. Yet, this is still hypothetical. 

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